Journal: Antibiotics
Article Title: Escaping the ESKAPE Antimicrobial Resistant Cycle with EVQ-218
doi: 10.3390/antibiotics15020224
Figure Lengend Snippet: Stable inhibition of Gram-positive ESKAPE pathogens by EVQ-218. Growth kinetics of Staphylococcus aureus and Enterococcus faecium were monitored across a concentration gradient of EVQ-218 (0.195–12.5 μg mL −1 ) at passage zero (P0) and passage twenty (P20). ( a , b ) S. aureus and ( c , d ) E. faecium . Across all concentrations, EVQ-218 produced a concentration-dependent inhibition of bacterial proliferation, characterized by delayed onset of exponential growth and reduced maximum optical densities relative to untreated controls. At P0, S. aureus exhibited complete inhibition at 6.25 μg mL −1 and partial suppression at 1.56–3.13 μg mL −1 , whereas E. faecium showed full inhibition at 12.5 μg mL −1 .
Article Snippet: E. faecium ATCC 19434 , 0.156 , P 0 –P 30 , same.
Techniques: Inhibition, Concentration Assay, Produced